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Caspase and TUNEL assays INS-1 832/3 cells were exposed overnight to thapsigargin (1 M) in serum-free RPMI plus 11 mM glucose

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The results showed that ROSE-010 (100 g) significantly reduced pain intensity in individuals with IBS compared to a placebo, with an overall odds ratio of 2.30 (95% CI: 1.53-3.46) and ROSE-010 (300 g) demonstrated greater effectiveness than placebo across all IBS subtypes, with consistent findings across multiple trials

GHK-Cu amplifies results through collagen gene upregulation, making this combination highly relevant for joint and tendon repair research